Defensin and Defensin-like family
| Superfamily: | Cysteine Rich Peptides |
| Contact: | Kevin Silverstein |
| Organization: | University of Minnesota |
| Source: | Silverstein, K.A.T., Moskal, W.A., Jr., Wu, H., Underwood, B.A., Graham, M.A., Town, C.D, and VandenBosch, K.A. (2007) Small cysteine peptides resembling antimicrobial peptides have been under-predicted in plants. Plant J. 51(2):262-80 |
| Criteria: | Iterative HMM family-based searches, starting with known cysteine-rich antimicrobial sequences. |
| Gene Name: | DEFL58 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Structural Annotation: | |
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| Gene Name: | DEFL59 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Comment: | TIGR Rice Transcript Assembly TA28648_4530. |
| Structural Annotation: | |
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| Gene Name: | DEFL60 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Comment: | Pseudogene. |
| Structural Annotation: | |
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| Gene Name: | DEFL61 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Structural Annotation: | |
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| Gene Name: | DEFL62 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Structural Annotation: | |
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| Gene Name: | DEFL63 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Structural Annotation: | |
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| Gene Name: | DEFL64 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Structural Annotation: | |
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| Gene Name: | DEFL65 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Structural Annotation: | |
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| Gene Name: | DEFL66 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Structural Annotation: | |
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| Gene Name: | DEFL67 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Structural Annotation: | |
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| Gene Name: | DEFL68 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Comment: | TIGR Rice Transcript Assembly TA28928_4530. |
| Structural Annotation: | |
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| Gene Name: | DEFL24 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Structural Annotation: | |
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| Gene Name: | DEFL23 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Structural Annotation: | |
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| Gene Name: | DEFL36 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Comment: | Pseudogene. |
| Structural Annotation: | |
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| Gene Name: | DEFL37 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Comment: | TIGR Rice Transcript Assembly CA760707 |
| Structural Annotation: | |
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| Gene Name: | DEFL76 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Comment: | Pseudogene. |
| Structural Annotation: | |
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| Gene Name: | DEFL19 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Structural Annotation: | |
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| Gene Name: | DEFL20 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Comment: | Rice FL_cDNA AK121438 |
| Structural Annotation: | |
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| Gene Name: | DEF4 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Comment: | High confidence supported by TIGR Rice Transcript Assembly TA20887_4530 |
| Structural Annotation: | |
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| Gene Name: | DEF5 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Comment: | High confidence supported by TIGR Rice Transcript Assembly TA19636_4530 |
| Structural Annotation: | |
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| Gene Name: | DEFL5 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Structural Annotation: | |
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| Gene Name: | DEFL77 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Structural Annotation: | |
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| Gene Name: | DEF10 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Structural Annotation: | |
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| Gene Name: | DEF11 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Structural Annotation: | |
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| Gene Name: | DEFL52 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Comment: | TIGR Rice Transcript assemblies CB097071, CA760767 and CA759130 |
| Structural Annotation: | |
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| Gene Name: | DEFL10 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Comment: | Pseudogene and this high-confidence prediction is based upon high similarity to 4 paralogous paralogs (3 are in adjacent positions). |
| Structural Annotation: | |
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| Gene Name: | DEFL26 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Structural Annotation: | |
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| Gene Name: | DEFL39 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Structural Annotation: | |
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| Gene Name: | DEFL54 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Comment: | TIGR Rice Transcript Assemblies AU101251 and C73342. |
| Structural Annotation: | |
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| Gene Name: | DEFL57 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| Comment: | Pseudogene with support of paralogous sequences. |
| Structural Annotation: | |
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| Gene Name: | DEFL35 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL35 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL7 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL7 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL4 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL4 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEF1 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEF1 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL78 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL78 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL1 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL1 - Defensin and Defensin-like DEFL family, expressed |
| Comment: | The CA annotation fits the alignments of the 11 paralogs. The CA annotation also includes the crucial last cysteine. |
| Structural Annotation: | |
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| Gene Name: | DEF2 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEF2 - Defensin and Defensin-like DEFL family |
| Comment: | Pseudogene and CA annotation includes crucial cysteines after the stop codon in this psuedogene. |
| Structural Annotation: | |
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| Gene Name: | DEF3 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEF3 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEF6 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEF6 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL72 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL72 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEF7 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEF7 - Defensin and Defensin-like DEFL family |
| Comment: | Rice FL-cDNA AK121915 and TIGR Rice Transcript Assemblies AU030229, AU058417, and CR279406. |
| Structural Annotation: | |
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| Gene Name: | DEFL73 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL73 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL74 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL74 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL71 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL71 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL75 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL75 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL38 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL38 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEF8 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEF8 - Defensin and Defensin-like DEFL family, expressed |
| Structural Annotation: | |
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| Gene Name: | DEFL40 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL40 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEF9 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEF9 - Defensin and Defensin-like DEFL family, expressed |
| Comment: | Rice FL-cDNA AK071283 and TIGR Rice Transcript Assemblies AK071283 and C73452. |
| Structural Annotation: | |
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| Gene Name: | DEFL50 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL50 - Defensin and Defensin-like DEFL family, expressed |
| Structural Annotation: | |
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| Gene Name: | DEFL51 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL51 - Defensin and Defensin-like DEFL family |
| Comment: | The CA two-exon gene has very strong similarity (8.8e-19) to other known DEFLs and is very close to another gene from the same subclass CRP0520. |
| Structural Annotation: | |
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| Gene Name: | DEFL49 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL49 - Defensin and Defensin-like DEFL family, expressed |
| Structural Annotation: | |
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| Gene Name: | DEF12 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEF12 - Defensin and Defensin-like DEFL family, expressed |
| Structural Annotation: | |
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| Gene Name: | DEFL8 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL8 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL9 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL9 - Defensin and Defensin-like DEFL family, expressed |
| Structural Annotation: | |
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| Gene Name: | DEFL11 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL11 - Defensin and Defensin-like DEFL family |
| Comment: | The CA gene structure fits very well with 3 nearly identical neighboring paralogs in CRP0220. The CA strucutre is supported by TA25281_4530. |
| Structural Annotation: | |
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| Gene Name: | DEFL27 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL27 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL21 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL21 - Defensin and Defensin-like DEFL family, expressed |
| Comment: | This annotation is supported by orthologs in wheat and barley. |
| Structural Annotation: | |
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| Gene Name: | DEFL12 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL12 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL2 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL2 - Defensin and Defensin-like DEFL family, expressed |
| Structural Annotation: | |
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| Gene Name: | DEFL13 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL13 - Defensin and Defensin-like DEFL family, expressed |
| Structural Annotation: | |
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| Gene Name: | DEFL53 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL53 - Defensin and Defensin-like DEFL family |
| Comment: | CA annotation is supported by 6 paralogs. |
| Structural Annotation: | |
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| Gene Name: | DEFL55 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL55 - Defensin and Defensin-like DEFL family, expressed |
| Structural Annotation: | |
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| Gene Name: | DEFL56 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL56 - Defensin and Defensin-like DEFL family |
| Comment: | The CA annotation is supported by a half dozen highly similar paralogs, many in close proximity. |
| Structural Annotation: | |
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| Gene Name: | DEFL47 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL47 - Defensin and Defensin-like DEFL family |
| Comment: | CA annotation has orthologs in other grass species. |
| Structural Annotation: | |
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| Gene Name: | DEFL14 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL14 - Defensin and Defensin-like DEFL family, expressed |
| Structural Annotation: | |
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| Gene Name: | DEFL69 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL69 - Defensin and Defensin-like DEFL family |
| Comment: | The CA annotatoin is fully supported by 6 similar paralogous genes and perfectly matches TIGR Rice Transcript Assembly CX116433. |
| Structural Annotation: | |
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| Gene Name: | DEFL70 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL70 - Defensin and Defensin-like DEFL family, expressed |
| Structural Annotation: | |
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| Gene Name: | DEFL81 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL81 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL6 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL6 - Defensin and Defensin-like DEFL family, expressed |
| Structural Annotation: | |
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| Gene Name: | DEFL45 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL45 - Defensin and Defensin-like DEFL family |
| Comment: | Community Annotation structure includes the signal peptide. |
| Structural Annotation: | |
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| Gene Name: | DEFL28 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL28 - Defensin and Defensin-like DEFL family, expressed |
| Structural Annotation: | |
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| Gene Name: | DEFL46 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL46 - Defensin and Defensin-like DEFL family |
| Comment: | This model includes an internal duplication of the defensin motif. |
| Structural Annotation: | |
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| Gene Name: | DEFL29 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL29 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL30 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL30 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL31 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL31 - Defensin and Defensin-like DEFL family |
| Comment: | The CA single-exon gene is consistent with numerous surrounding paralogous genes in a large defensin cluster. |
| Structural Annotation: | |
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| Gene Name: | DEFL22 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL32 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL32 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL32 - Defensin and Defensin-like DEFL family |
| Comment: | The CA single-exon gene is consistent with numerous surrounding paralogous genes in a large defensin cluster. |
| Structural Annotation: | |
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| Gene Name: | DEFL33 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL33 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL79 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL79 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL80 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL80 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL34 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL34 - Defensin and Defensin-like DEFL family |
| Comment: | The CA annotation is confirmed by Rice EST Read Pair CI739431 CI521227 and is similar to 8 paralogous genes. |
| Structural Annotation: | |
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| Gene Name: | DEFL25 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL25 - Defensin and Defensin-like DEFL family |
| Comment: | The CA annoation fits well with 3 similar paralogs (2 of them adjacent to this gene). |
| Structural Annotation: | |
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| Gene Name: | DEFL15 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL15 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL41 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL42 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL42 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL42 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL48 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL48 - Defensin and Defensin-like DEFL family, expressed |
| Structural Annotation: | |
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| Gene Name: | DEFL44 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL44 - Defensin and Defensin-like DEFL family |
| Comment: | CA gene structure includes defensin motif. |
| Structural Annotation: | |
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| Gene Name: | DEFL16 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL16 - Defensin and Defensin-like DEFL family |
| Comment: | CA gene structure is supported by 6 similar paralogous genes, one of them adjacent to this gene. |
| Structural Annotation: | |
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| Gene Name: | DEFL17 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL17 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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| Gene Name: | DEFL18 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL18 - Defensin and Defensin-like DEFL family |
| Comment: | Correction is consistent with gene structure of 6 paralogs, and CA annotation includes the crucial last four cysteines. |
| Structural Annotation: | |
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| Gene Name: | DEFL43 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL43 - Defensin and Defensin-like DEFL family, expressed |
| Structural Annotation: | |
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| Gene Name: | DEFL3 |
| Gene Description: | Defensin and Defensin-like (DEFL) family |
| MSU Annotation: | DEFL3 - Defensin and Defensin-like DEFL family |
| Structural Annotation: | |
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This work is supported by grants (DBI-0321538/DBI-0834043) from the National Science Foundation and funds from the Georgia Research Alliance, Georgia Seed Development, and University of Georgia.